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Solitary fibrous tumor of all sites: outcome of late recurrences in 14 patients

Giacomo G Baldi1*, Silvia Stacchiotti1, Valentina Mauro2, Angelo P Dei Tos3, Alessandro Gronchi4, Ugo Pastorino4, Leonardo Duranti4, Salvatore Provenzano1, Andrea Marrari1, Michela Libertini1, Silvana Pilotti2 and Paolo G Casali1

Author Affiliations

1 Department of Cancer Medicine, Adult Sarcoma Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy

2 Department of Pathology, Experimental Molecular Pathology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy

3 Department of Anatomic Pathology, General Hospital of Treviso, P.zza Ospedale 1, Treviso, 31100, Italy

4 Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy

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Clinical Sarcoma Research 2013, 3:4  doi:10.1186/2045-3329-3-4

Published: 3 April 2013

Abstract

Background

We explore the pattern of late recurrence (LR) in solitary fibrous tumor (SFT), focusing on histopathologic characteristics, clinical presentation and patients (pts) outcome.

Methods

Clinical records of all pts with confirmed pathologic diagnosis of SFT treated at our Institution from 2005 to 2011 were reviewed. We analysed the data of pts who relapsed ≥10 years after initial diagnosis.

Results

A total of 14 pts were identified. The primary site of origin was pleura (5 pts), pelvis (4 pts), head and neck (3 pts) and retroperitoneum (2 pts). Primary tumor was a typical SFT in 5 and a malignant SFT in 7 out of 12 pts whose tumor tissue was available for revision. The median time to first recurrence was 12 years (range 10–23). The first relapse was local in 11 cases, distant in 3. Five pts later developed distant metastases. Four out of 5 cases of typical SFT developed distant metastases in spite of their initial benign aspect. No patient was disease-free at the time of the analyses.

Conclusion

Our series suggests that LR can occur in SFT and some cases can behave aggressively even in the absence of any primary morphologic evidence of malignancy. A prolonged follow-up may be advisable.

Keywords:
Sarcoma; Solitary fibrous tumor; Hemangiopericytoma; Outcome; Late recurrence