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Open Access Letter to the Editor

The rule of fives, a simple way to stratify risk for primary gastrointestinal stromal tumors (GIST)

Robert G Maki

Author Affiliations

Departments of Medicine, Pediatrics, and Orthopaedics, Mount Sinai School of Medicine, New York, NY, 10029-6574, USA

Clinical Sarcoma Research 2012, 2:21  doi:10.1186/2045-3329-2-21

Published: 5 October 2012


The current AJCC version 7 staging system is a lugubrious means to classify gastrointestinal stromal tumors with respect to their risk and need for adjuvant systemic therapy. The rule of fives, suggested here, is a means to quickly assess whether a given gastrointestinal stromal tumor is low vs intermediate-high risk.

Gastrointestinal stromal tumor; GIST; Staging; Adjuvant therapy