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Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma

Daniela Katz1, Piyaporn Boonsirikamchai2, Haeson Choi2, Alexander J Lazar3, Wei-Lein Wang3, Lianchun Xiao4, Min S Park1, Vinod Ravi1, Robert S Benjamin1 and Dejka M Araujo1*

Author Affiliations

1 Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

2 Department of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

3 Department of Pathology & Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

4 Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Clinical Sarcoma Research 2012, 2:2  doi:10.1186/2045-3329-2-2

Published: 24 January 2012

Abstract

Background

Myxoid liposarcoma (MLS) is a soft tissue sarcoma with adipocytic differentiation characterized by a unique chromosome rearrangement, t(12;16)(q13;p11). The exact efficacy of chemotherapy in MLS has not been clearly established.

Patients and methods

We retrospectively analyzed the records of 37 histologically confirmed MLS patients who were treated at the University of Texas MD Anderson Cancer Center from January 2000 to December 2009 with doxorubicin 75-90 mg/m2 over 72 hours combined with ifosfamide 10 gm/m2 in the first-line setting. Response was assessed using RECIST and Choi criteria. The Kaplan-Meier method and log-rank test was used to estimate clinical outcomes.

Results

The median follow-up period was 50.1 months. The overall response rates were 43.2% using RECIST and 86.5% using the Choi criteria. The 5-year disease-free survival rate was 90% for patients with resectable tumors. Median time to progression and overall survival time for the advanced-disease group were 23 and 31.1 months, respectively.

Conclusion

Our study demonstrates that doxorubicin-ifosfamide combination therapy has a role in the treatment of MLS. The Choi criteria may be more sensitive in evaluating response to chemotherapy in MLS.

Keywords:
Choi criteria; doxorubicin; ifosfamide; myxoid liposarcoma